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Struttura Dipartimento di Biologia
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Settore scientifico BIO/10 - BIOCHIMICA
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Orario di ricevimento
Martedì dalle 09:30 alle 10:30 Vallisneri, VI.piano Sud L'orario riguarda solo 2015 fino a giugno.
(aggiornato il 29/04/2015 13:49)

Proposte di tesi
Studio di canali ionici e del loro ruolo nel signaling in cellule vegetali in relazione a stress e in cellule animali in relazione ai tumori. Le tecniche utilizzate comprendono tecniche di biologia cellulare, biochimica, biofisica, biologia molecolare e esperimenti in vivo.

Curriculum Vitae
Affiliation: Dept. of Biology

Position: Associate Professor at the Department of Biology of the University of Padova, Italy (

Education and academic career:

07/1988 M.Sc. in Biology and Chemistry - Eotvos Lorand University of Budapest, Hungary
1989-1994 Ph.D. student at the Department of Biomedical Sciences of the University of Padova
1992 Short-term EMBO fellow at Biozentrum, Basel, Switzerland
10/1994 Ph.D. in Molecular and Cellular Biology and Pathology, University of Padova, Italy
1995-1996: EMBO postdoctoral fellow at the Institute of Physiology of the University of Tuebingen
1997-1998: Postdoctoral fellow at the Department of Biomedical Sciences of the University of Padova
1998-2004: Assistant Professor in Biochemistry, at the Department of Biology of the University of Padova
Since 01/2005 Associate Professor in Biochemistry at the Department of Biology of the University of Padova
Since 2012: Editorial Board Member of Scientific Reports of NPG
Since 2013: Associate Member of the Iontrac International Training Network
2014: Co-Editor of a Special Issue of Cell Calcium
2014: Associate Member of the Institute of Neuroscience (CNR)
2015: Vice-Chair of a new Gordon Conference on Intracellular Ion Channels and Transporters

1995-1996: EMBO long-term fellowship
2000: CNR Young Investigator Grant
2002: selected as EMBO Young Investigator.
From 2005: selected and acting as expert evaluator for Marie-Curie fellowships of EEC.
2011: selected as member of Top Italian Scientists (H factor>30)
2014: habilitation for Full Professorship in Biochemistry and in Plant Physiology

Invited Seminars (from 2013):
2013: Ion channel and cancer Workshop, Barcellona, Spain.
2013: CEA at Grenoble, France (Dr. G. Finazzi).
2013: University of Kiel, Germany (Prof. H. Kalthoff).
2014: American Biophysical Society Meeting, San Francisco, USA.
2014: Gordon Conference on Chloroplasts and Mitochondria, Ciocco, Italy
2014: European Bioenergetics Conference, Lisbon, Portugal.
2014: 25th Ion Channel meeting, Oleron, France.
2014: FISV (Life Sciences), Pisa, Italy
2015: FEBS Workshop on Plant organellar signalling (Keynote lecture), Primosten, Croatia;
2015: German Physiological Society Meeting, Magdeburg.
2015: European Calcium Society Calcium and Cell Fate 2015 workshop, France.
2015: International Conference on Ion Channels, transporters and Cancer, London, UK
2016: Plant membrane biology, Annapolis USA
2016: EBEC, Riva del Grada, Italy
2016: Photosynthesis Satellite Meeting, Belgium

International collaborations:
E. Gulbins (Essen, Germany), N. Uozumi (Tohuku, Japan), F. Lang (Tuebingen, Germany), KG. Chandy (Irvine, USA), H. Kalthoff (Kiel, Germany) G. Finazzi (Grenoble, France), R. Wagner (Osnabrueck, Germany), E. Szegezdi (Galway, Ireland), T. Shikanai (Kyoto, Japan), C. Spetea (Gothenburg, Sweden), C. Chang (Berkeley, USA).

Grants as coordinator:
National grants of the Italian Ministry (2007, 2009, 2011), Young Investigator Grant of the CNR (2000) EMBO Young Investigator Grant (2003), University of Padova Grants (2008, 2010, 2012, 2014), Italian Association for Cancer Research (2007, 2011, 2014). Human Frontiers Science Program (2015).

Co-author of 120 peer-reviewed papers. Total citation: 8681 (Google Scholar).
H factor: 46

Aree di ricerca
Considerable information is available in the rapidly developing field of ion channels about the molecular identification and biophysical characterization of ion channels in the plasma membrane, while relatively little is known about organellar channels, a topic of interest in the group. In particular, ion channels seem to regulate important processes in both energy-producing organelles: mitochondria and chloroplasts. For example, the molecular identification of a mitochondrial potassium channel led to the elucidation of its central role in apoptotic signalling in lymphocytes and to an efficient and selective killing of cancer cells in vivo, via pharmacological targeting of cancer cells expressing the channel. Likewise, recent discovery of identity of the mitochondrial calcium uniporter is expected to lead to further understanding of its role in various cellular processes. In plants, ion channels of both the chloroplast inner envelope and the thylakoid membranes are thought to participate in the regulation of photosynthesis, an essential physiological process. Genetic evidence supporting this hypothesis has recently been obtained in photosynthetic cyanobacteria and higher plants. Elucidation of the molecular mechanisms which regulate photosynthesis might lead to practical benefits in the future. In summary, the aims of the running projects in the laboratory are to provide decisive information about the involvement of mitochondrial and chloroplasts ion channels in the regulation of bioenergetic and related processes by comparing activities in wild-type and mutant organisms, bearing deletions or mutations of genes encoding organellar channels

Selected publications

Szabò I., Zoratti M. Mitochondrial channels: ion fluxes and more.
Physiol. Rev. 2014, 94(2): 519-608.

Carraretto L., Formentin E., Teardo E., Checchetto V., Tomizioli M., Morosinotto T., Giacometti G.M., Finazzi G., Szabò I.A thylakoid-located two-pore potassium channel controls photosynthetic light utilization in plants.
Science 2013, 342: 114-8.

Checchetto V., Segalla A., Allorent G., La Rocca N., Leanza L., Giacometti G.M., Uozumi N., Finazzi G., Bergantino E., Szabò I.A thylakoid potassium channel is required for efficient photosynthesis in cyanobacteria.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109: 11043-8.

Leanza L., Henry B., Sassi N., Zoratti M., Chandy K.G., Gulbins E., Szabò I.
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
EMBO Molecular Medicine 2012, 4: 577-93.

De Stefani D., Raffaello A., Teardo E., Szabò I., Rizzuto R.
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Nature 2011, 476: 336-40.

Szabò I., Lepple-Wienhues A., Kaba K.N., Zoratti M., Gulbins E., Lang F.Tyrosine kinase dependent activation of a chloride channel in CD95-induced apoptosis.
Proc. Natl. Acad. Sci. USA. 1998, 95: 6169-74.

Zoratti M., Szabò I.
The mitochondrial permeability transition.
Biochim. Biophys. Acta 1995, 1241: 139-76.

Pubblicazioni del docente in PDF: F96A23F33B8F4CEF828789DCACA1A770.pdf

Insegnamenti dell'AA 2017/18
Corso di studio (?) Curr. Codice Insegnamento CFU Anno Periodo Lingua Responsabile
Info e programma immatricolati A.A. 2017/18
Attuale A.A. 2017/18
»   SCP4067771 BIOCHIMICA 1
Info e programma immatricolati A.A. 2017/18
Attuale A.A. 2017/18
7 I Secondo
»   SCP4067772 BIOCHIMICA 2
Info e programma immatricolati A.A. 2017/18
Attuale A.A. 2017/18
6 I Secondo
SC1175 005PD SCN1028730 BIOCHIMICA
Info e programma immatricolati A.A. 2017/18
Attuale A.A. 2017/18
8 I Primo
SC1175 006PD SCN1028730 BIOCHIMICA
Info e programma immatricolati A.A. 2016/17
Attuale A.A. 2017/18
8 II Primo