Orario di ricevimento
(aggiornato il 29/06/2013 15:41)
Proposte di tesi
The group activities is focused on the delivery of drugs and biopharmaceutics. Availability for experimental master thesis for 2018 on the following projects:
• Development of responsive gold nanoparticles for anticancer drug delivery. Novel gold nanoparticles will be designed and assembled by combining functional polymers bearing anticancer drugs for the intracellular delivery. Furthermore, gold nanoparticles will be tested for external stimuli activation to leverage the anticancer activities of drugs
• Study of novel synthetic polymers for the delivery of biopharmaceutics. This project is aimed at preparing and studying amphiphilic polymers and poly-ionic materials that can be used to formulate and deliver biologically active proteins and oligonucleotides.
• Development of liposomes for anticancer drug delivery. Lipidic vesicles will be prepared with a variety of functional coating agents to promote selective biodistribution of drugs in the cancer and access to the intracellular space. Special emphasis will be dedicated to generate and characterize novel amphiphilic polymers for liposome coating, targeting units and/or cell penetration enhancers.
• Development of colloidal self-assembling systems for the delivery of anticancer drugs and immunostimulating drugs through alternative routes of administration (local, nasal, intravescical, cutaneous, etc).
• Delivery of drugs by soluble polymers. The focus of this thesis project is to generate “polymer therapeutics” through the use of water soluble natural polymers as carriers of drugs. Functional components will also be bound to the polymer to ensure the controlled release of drugs in a selected disease site. Bioconjugation and biological characterization are the main activities within this project.
Since October 2014: associate professor at the Department of Pharmaceutical and Pharmacological Sciences, University of Padova, where I teaches “Technology of delivery and controlled release of drugs” and a module of “Delivery and formulation of Biotech drugs” to undergraduated and PhD students.
2004-2014: assistant professor at the Department of Pharmaceutical Sciences, University of Padova.
2009: recipient of a three-years grant from European Commission in the framework of the FP VII (NanoSCI ERAnet). The project aimed at investigating nanocarriers for siRNA delivery to silence key proteins in the cancer development using pH responsive copolymers.
2005 and 2008: invited scientist at Northeastern University - Boston (USA), Prof. V. Torchilin. He investigated responsive micelles and targeted liposomes for site-selective drug delivery to the tumor tissue and the brain.
2004: Ph.D. in “Pharmaceutical Sciences”, University of Padova.
2003: research contract by the Faculty of Pharmacy at the University of Padova.
2002: visiting scientist at the University of Paris-Sud XI (Prof. P. Couvreur) and at I.B.M.C of the University of Strasbourg. Development of cyclodextrin based macromolecular carriers for the delivery of anticancer drugs.
2000: training fellowship at the Department of Pharmaceutical Sciences of the University of Padua to investigate "Macromolecular systems for drug delivery".
1998-1999: training fellowship at Center for Innovative Biotechnologies (CRIBI) in Padova
1998: degree in Chemistry and Pharmaceutical Technologies.
I authored 46 peer-reviewed publications, 3 book chapters, 3 international patents and over 80 posters and oral presentations at international symposiums and 5 invited lectures. I have served as Guest Editor for the Journal of Drug Delivery.
Since the beginning of my career my interest has been focused on the development of supramolecular drug delivery systems. I started my investigations on the structure/function relationship of polypeptides with biological activity. The experience acquired was exploited later on for the conjugation of proteins with biocompatible polymers developing original methods for the site-specific conjugation through "grafting-to" and "growing-from" procedures. I also investigated polymer/protein physical assembling which allowed for the modulation of the pharmacokinetic profile of therapeutic proteins.
My interests in the last years have focused on the development of “smart” nanocarriers for drug and oligonucleotides delivery to the tumour. In collaboration with Prof V. Torchilin, I have developed pH sensitive micelles and liposomes for site-selective delivery of anticancer drugs. With Prof. Torchilin I also designed nanocarriers capable of actively targeting the central nervous system.
The experience acquired in USA laboratories has open the investigation of a variety of responsive platforms for drug delivery with the aim to improve the site-selectivity of the nanocarriers and to locally and temporally control the release of loaded drugs.
I provided a remarkable contribution for the advancement of drug nano-vehicles with enhanced "homing" capacity conferred by the cross-talk of surface functional components.
Insegnamenti dell'AA 2016/17
Altre attività di cui il docente è responsabile per l'AA 2016/17
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